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Monday, April 12, 2021

CDC Panel: No COVID-19 Vaccine Security Surprises

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Jan. 27, 2021 — The U.S. is sort of 6 weeks into its historic marketing campaign to vaccinate Individuals towards the virus that causes COVID-19, and to date, the 2 vaccines in use look remarkably low-risk, in accordance with new information offered at present at a gathering of vaccine consultants that advise the CDC.

With 23.5 million doses of the Pfizer and Moderna vaccines now given, there have been only a few severe negative effects. As well as, deaths reported after folks received the vaccine don’t appear to be associated to it.



The most typical signs reported after vaccination have been ache the place folks received the shot, fatigue, headache, and muscle soreness. These have been extra frequent after the second dose. As well as, about 1 in 4 folks reported fever and chills after the second shot.

“On the entire, I assumed it was very reassuring,” stated William Schaffner, MD, an infectious illness professional with Vanderbilt College Faculty of Medication in Nashville who listened to the displays.

The CDC is accumulating security info by a number of channels. These embody a brand new smartphone-based app referred to as V-Safe, which collects every day info from individuals who’ve been vaccinated; the federal Vaccine Opposed Occasion Reporting System, or VAERS, which accepts reviews from anybody; and the Vaccine Safety Datalink, which is a collaboration between the CDC and 9 main hospital programs. There’s additionally CISA, the Scientific Immunization Security Evaluation Mission, a collaboration between the CDC and vaccine security consultants.

After surveying these programs, consultants heading the security committee for the CDC’s Advisory Committee on Immunization Practices say there have been few severe negative effects reported.

Very hardly ever, extreme allergic reactions — referred to as anaphylaxis — have occurred after vaccination. There have been 50 of those circumstances reported after the Pfizer vaccine and 21 circumstances reported after the Moderna vaccine so far. Practically all of them — 94% of the anaphylaxis circumstances after Pfizer vaccines and 100% of these after Moderna’s vaccine — have been in ladies, although it’s not clear why.

That interprets to a charge of about 5 circumstances of anaphylaxis for each million doses of the Pfizer vaccine and about three for each million doses of the Moderna vaccine. Most of those happen inside quarter-hour after getting a vaccine dose, with one reported so long as 20 hours after the shot.

The CDC suspects these could also be associated to an ingredient referred to as polyethylene glycol, or PEG. PEG is part of the particles that slip the vaccines’ mRNA into cells with directions to make the spike protein of the virus. Cells then categorical these spikes on their surfaces so the immune system can study to acknowledge them and make defenses towards them. PEG is a typical ingredient in lots of medication and infrequently triggers anaphylaxis.

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